#Kathmandu University
#MBBS II [February 7, 2024]
#SECTION “B”
1. Define family and its type. What is the role of family in health and disease? (3 + 2 = 5)
2. Describe the natural history of disease and discuss the levels of prevention. (2 + 3 = 5)
3. Classify epidemiological studies. Mention the differences between case control and cohort studies.(2 + 3 = 5)
4. Define Medical Entomology. What type of transmission cycles are involved in the spread of arthropod borne disease?(1 + 4 = 5)
5. Write short notes on:
a. Principles of medical ethics (2.5)
b. Objectives of community diagnosis programme (2.5)
6. Define “Safe and Wholesome water.” What are the methods of water purification on large scale?(2 + 3 = 5)
#SECTION “C”
#Problem – I
7. A three-year-old boy was brought to the hospital. He had recurrent attacks of diarrhea for the last few months. He had edema in the legs and arms, his skin showed diffuse pigmentation. The child was apathetic. The child belonged to a joint family of eight members with poor socio-economic conditions. The weaning of bottle milk was started to the child at the age of three months.
a. What is your provisional diagnosis? Give reasons to support your answer. (2)
b. Enumerate the major nutritional problems in Nepal. (2)
c. Write in brief the methods of nutritional status assessment of under-five children in a community. (3)
d. Discuss preventive measures of Protein Energy Malnutrition. (3)
#Problem – II
8. Hari Pariyar is a 47-year-old poor farmer from Kavre. He has been living with his three young children and a wife in a rented room in Bhaktapur of 12 feet by 10 feet size. The room has an attached kitchen and has very poor ventilation. For the last two months, Hari has been suffering from on and off cough and fever in the evening. He complains of decreased appetite and has significantly lost his weight. Further, he gets easily tired these days and skips his work frequently. His wife has forced him to go to the Bhaktapur TB hospital for a check-up. The doctor examined him and advised him to go for sputum test.
a. What is the probable diagnosis? Justify. (2)
b. Which additional information would you like to ask in the history? (2)
c. Besides the clinical features, which determinants of health are important in making a diagnosis in this case? List them. (2)
d. Is his place of residence overcrowded? Explain. (2)
e. Which additional tests do you think can confirm the disease? (2)
The Blueprint................
#SECTION “B”
#1. Define family and its types. Role of family in health and disease. (3+2)
Family (Definition):
A family is a group of persons related by blood, marriage, or adoption, usually living together under one roof, sharing a common kitchen, and interacting with each other.
Types of family:
Nuclear family: Parents and their unmarried children
Joint/Extended family: Two or more generations living together
Three-generation family: Grandparents, parents, and children living together
Role of family in health and disease:
Promotes health through nutrition, care, emotional support, and healthy behaviors
Influences occurrence, prevention, and management of disease through living conditions, care-seeking behavior, and transmission patterns
#2. Describe the natural history of disease and discuss the levels of prevention.(2+3)
Natural history of disease (2 marks)
The natural history of disease refers to the progression of a disease in an individual from its inception to its final outcome, in the absence of intervention.
Phases:
Pre-pathogenesis phase: Interaction of agent, host, and environment before disease onset
Pathogenesis phase: Development of disease → clinical illness → recovery, disability, or death
Levels of prevention (3 marks)
Primordial prevention
Prevention of the emergence of risk factors by improving social, economic, and environmental conditions
(e.g., promoting healthy lifestyle, tobacco control policies)Primary prevention
Prevention of disease occurrenceHealth promotion
Specific protection
Secondary prevention
Early detection and prompt treatment to halt disease progressionScreening
Early diagnosis and treatment
Tertiary prevention
Reduction of disability and complications and restoration of functionDisability limitation
Rehabilitation
#3. Classify epidemiological studies. Differences between case-control and cohort studies. (2+3)
#Classify Epidemiological Studies (2 marks)
Epidemiological studies are classified as:
Descriptive studies
Case report
Case series
Cross-sectional studies
Analytical studies
Case–control studies
Cohort studies
Experimental (Interventional) studies
Randomized controlled trials (RCTs)
Field trials
Community trials
Differences between case-control and cohort studies:
Basis | Case–Control Study | Cohort Study |
|---|---|---|
Direction | From disease to exposure | From exposure to disease |
Comparison groups | Cases (diseased) and controls (non-diseased) | Exposed and non-exposed groups |
Best suited for | Rare diseases | Rare exposures |
Measure of association | Odds Ratio (OR) | Relative Risk (RR) |
Time & cost | Less time-consuming and inexpensive | More time-consuming and costly |
#4. Define Medical Entomology. What type of transmission cycles are involved in the spread of arthropod borne disease? (1+4)
#Define Medical Entomology (1 mark)
Medical entomology is the branch of science that deals with the study of arthropods of medical importance, particularly those involved in the transmission of diseases to humans.
#Transmission cycles involved in arthropod-borne diseases (4 marks)
Man–arthropod–man cycle
Disease is transmitted from an infected human to another human through an arthropod vector
Example: Malaria, Filariasis
Animal–arthropod–man cycle (Zoonotic cycle)
Infection is maintained among animals and transmitted to humans by arthropods
Example: Plague, Japanese encephalitis
Man–arthropod–animal cycle
Humans act as a source of infection for animals via arthropods
Example: Human trypanosomiasis
Transovarial (vertical) transmission
Infection is passed from adult arthropod to its offspring through eggs
Example: Scrub typhus, Tick-borne diseases
#5. Short notes
a. Principles of medical ethics (2.5):
Autonomy
Respecting the patient’s right to make informed decisions about their own health care.
Beneficence
Acting in the best interest of the patient to promote well-being and prevent harm.
Non-maleficence
“Do no harm” – avoiding actions that may cause unnecessary harm or injury to the patient.
Justice
Fair and equitable distribution of healthcare resources and services.
Confidentiality (optional but often included)
Protecting patient information and maintaining privacy
b. Objectives of community diagnosis programme (2.5):
Identify health problems
To determine the major health issues affecting a specific community.
Assess health needs and resources
Evaluate the availability of health services, facilities, and manpower.
Plan and prioritize interventions
Guide the development of targeted health programs based on community needs.
Monitor and evaluate
Assess the effectiveness of health interventions and programs.
Promote community participation
Involve community members in identifying problems and implementing solutions.
#6. 6. Define “Safe and Wholesome water.” What are the methods of water purification on large scale (2+3)
#Define “Safe and Wholesome Water” (2 marks)
Safe and wholesome water is water that is free from pathogenic organisms, harmful chemicals, and toxic substances, and is aesthetically acceptable in terms of taste, color, and odor. It should be suitable for drinking, cooking, and domestic use without causing health hazards.
#Methods of Large-Scale Water Purification (3 marks)
Storage
Allowing water to settle so that suspended solids can sediment naturally.
Filtration
Slow sand filters or rapid sand filters to remove suspended particles, turbidity, and microorganisms.
Disinfection/Chlorination
Adding chlorine or other disinfectants to kill pathogenic microorganisms.
Coagulation and Sedimentation
Adding coagulants (e.g., alum) to clump fine particles, followed by settling.
Other methods (if applicable)
UV irradiation, ozonation, or fluoridation depending on local requirements.
#SECTION “C”
#Problem – I
7. A three-year-old boy was brought to the hospital. He had recurrent attacks of diarrhea for the last few months. He had edema in the legs and arms, his skin showed diffuse pigmentation. The child was apathetic. The child belonged to a joint family of eight members with poor socio-economic conditions. The weaning of bottle milk was started to the child at the age of three months.
a. What is your provisional diagnosis? Give reasons to support your answer. (2)
b. Enumerate the major nutritional problems in Nepal. (2)
c. Write in brief the methods of nutritional status assessment of under-five children in a community. (3)
d. Discuss preventive measures of Protein Energy Malnutrition. (3)
#a. Provisional diagnosis with reasons. (2)
Diagnosis: Kwashiorkor
Reasons:
Edema, skin pigmentation, apathy
Early bottle feeding, poor socioeconomic condition
#b. Major nutritional problems in Nepal. (2)
Protein Energy Malnutrition
Micronutrient deficiencies (iron, iodine, vitamin A)
#c. Nutritional status assessment of under-5 children. (3)
Anthropometry (weight, height, MUAC)
Clinical assessment
Dietary assessment
#d. Preventive measures of Protein Energy Malnutrition. (3)
Exclusive breastfeeding and appropriate complementary feeding
Nutrition education and food security
Growth monitoring and early intervention
#Problem – II
8. Hari Pariyar is a 47-year-old poor farmer from Kavre. He has been living with his three young children and a wife in a rented room in Bhaktapur of 12 feet by 10 feet size. The room has an attached kitchen and has very poor ventilation. For the last two months, Hari has been suffering from on and off cough and fever in the evening. He complains of decreased appetite and has significantly lost his weight. Further, he gets easily tired these days and skips his work frequently. His wife has forced him to go to the Bhaktapur TB hospital for a check-up. The doctor examined him and advised him to go for sputum test.
a. What is the probable diagnosis? Justify. (2)
b. Which additional information would you like to ask in the history? (2)
c. Besides the clinical features, which determinants of health are important in making a diagnosis in this case? List them. (2)
d. Is his place of residence overcrowded? Explain. (2)
e. Which additional tests do you think can confirm the disease? (2)
#a. Probable diagnosis with justification. (2)
Diagnosis: Pulmonary Tuberculosis
Justification:
Chronic cough, evening fever, weight loss
Poor living condition and overcrowding
#b. Additional history to ask. (2)
History of contact with TB patient
Past TB treatment or HIV status
#c. Determinants of health important in diagnosis. (2)
Socioeconomic status
Housing and ventilation
#d. Is his residence overcrowded? Explain. (2)
Yes.
Overcrowding exists when available floor space per person is less than the recommended standard; 12×10 ft room for 5 persons indicates overcrowding.
#e. Additional tests to confirm the disease. (2)
Sputum smear microscopy / GeneXpert
Chest X-ray