#Kathmandu University

University Examination
January/February 2026

Level: MBBS
Exam: II MBBS
Paper: VII Reproductive System
Time: 2 hours 30 minutes
Marks: 50
Date: February 20, 2026

#INSTRUCTION TO THE CANDIDATE

• Answer each section in a separate answer book.
• Write brief, relevant and legible answers.
• Illustrate your answer with well labeled diagrams wherever required.
• All questions are compulsory.

#SECTION “B”

#Short Answer Questions

1.
a. Describe the development of testes with its congenital anomalies. [3]
b. Describe the supports of uterus with their applied anatomy. [2]
c. Mention the layers of scrotum with applied anatomy. [2]

2.
Write down the biochemical test for the diagnosis of infertility in female. [2]

3.
a. Explain the laboratory diagnosis of primary syphilis. [2]
b. Draw a well labelled diagram of HIV virus and mention about the role of its important structure in replication. [3]

4.
a. Classify testicular tumors. Write down microscopic morphology of seminoma of testis. [2+2=4]
b. Write differences between complete and partial hydatidiform mole. [3]

5.
a. Write down the pharmacological basis of combining Estrogen with Progestin for contraception. [3]
b. Write down the mechanism of action of Finasteride. [2]

6. Explain the followings:
a. Mechanism of fertilization of ovum [2]
b. Blood-testis barrier [2]

#SECTION “C”

#Problem Based Questions

#Problem – I

A 32-year-old female presented with amenorrhea for 3 months in Obstetric department. Her pregnancy test was positive. She gave history of recurrent spontaneous abortion in the past. On examination, fetal heart sound was absent and uterus was too large for estimated duration of pregnancy. Doctor suspected the congenital infection in the fetus and sent for further investigations.

a. List significant pathogens included in TORCH group. For each of the pathogens, mention the mode of transmission in pregnant female. [2+2=4] (Microbiology)

b. Write the function and life span of human chorionic gonadotropin (β-hcg) in pregnancy. [3] (Physiology)

c. Enlist drugs that should be avoided during pregnancy with its teratogenic adverse effects. [3] (Pharmacology)

#Problem – II

A 60-year-old lean and thin postmenopausal Para 6 widow farmer and smoker from rural area was presented with a history of foul smelling per vaginal discharge and bleeding, not relieved by multiple treatments. Her Pap smear report mentioned Low grade Squamous Intra-epithelial Lesion of cervix for which she lost follow up. Examination shows cauliflower like growth in the cervix for which biopsy was taken which revealed moderately differentiated squamous cell carcinoma of cervix and was treated for that.

a. Describe microanatomy of the affected organ. [Anatomy] [4]

b. Explain why estrogen decreases in postmenopausal state like in the above case. Describe its synthesis. [Biochemistry] [1+2=3]

c. List the risk factors for carcinoma of cervix. [Pathology] [3]